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88/100May 2026 review (v3.0 rubric); v4.1 re-score pending
Offering and price for this peptide not verified in the October 15, 2026 update.
Read review →Sexual Health · Peptide
Kisspeptin
Released: Last reviewed:
Kisspeptin is a hypothalamic peptide that activates the gonadotropin-releasing hormone (GnRH) system upstream of the entire reproductive axis. Studied for hypothalamic amenorrhea, hypogonadism, and libido.
Kisspeptin at a glance
Kisspeptin is a hypothalamic peptide that activates the gonadotropin-releasing hormone (GnRH) system upstream of the entire reproductive axis. Studied for hypothalamic amenorrhea, hypogonadism, and libido. Mechanism: Hypothalamic neuropeptide. Typical route: Subcutaneous, intranasal. FDA status: Not FDA-approved as a finished drug product. Used in clinical research and dispensed by specialty compounding pharmacies for off-label hypogonadism, hypothalamic amenorrhea, and libido protocols.
Drug classHypothalamic neuropeptide
Half-life~20-30 minutes
RouteSubcutaneous, intranasal
Common dosing50-200 mcg, 2-3x/week
FDA statusNot approved
Available throughSee the dated FDA status notice above
Mechanism of action
Kisspeptin activates the KISS1R receptor on GnRH neurons in the hypothalamus, stimulating pulsatile GnRH release. GnRH then drives pituitary LH/FSH release, which in turn stimulates testicular testosterone or ovarian estradiol production. Kisspeptin therefore acts upstream of testosterone or HCG protocols.
Dosing reference
Subcutaneous: 50-200 mcg, two to three times weekly. Some protocols dose intranasally at higher amounts. Optimal dosing for sexual-health applications is not standardized.
Dosing information is provided for educational reference and is not medical advice. Patients should not initiate or modify any peptide regimen without consulting a licensed clinician. See our medical disclaimer.
FDA status & regulatory framework
Not FDA-approved as a finished drug product. Used in clinical research and dispensed by specialty compounding pharmacies for off-label hypogonadism, hypothalamic amenorrhea, and libido protocols.
U.S. telehealth providers that work with Kisspeptin
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80/100May 2026 review (v3.0 rubric); v4.1 re-score pending
Offering and price for this peptide not verified in the October 15, 2026 update.
Read review →–
76/100May 2026 review (v3.0 rubric); v4.1 re-score pending
Offering and price for this peptide not verified in the October 15, 2026 update.
Read review →Related sexual-health peptides
Frequently asked questions about Kisspeptin
How does kisspeptin differ from testosterone replacement?
Testosterone replacement suppresses the body's own hormone production. Kisspeptin activates the body's natural GnRH-LH-testosterone axis, preserving (or restoring) endogenous production rather than replacing it.
Can kisspeptin be used during testosterone replacement?
Combining kisspeptin with exogenous testosterone may not produce additive effects; testosterone replacement suppresses the upstream HPG axis. Kisspeptin is most useful where preserving endogenous production matters (fertility, post-cycle therapy, hypothalamic amenorrhea).
References
- The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014;20(4):485-500. PMID: 24615662
- Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest. 2017;127(2):709-719. PMID: 28112678
Sources are peer-reviewed where available. PubMed (PMID) links resolve to NCBI's PubMed database. FDA links resolve to the U.S. Food and Drug Administration. Citations were last verified 2026-05-11.