Key facts
Mechanism of action
Coenzyme essential for cellular energy metabolism, DNA repair, and sirtuin activity. NAD+ levels decline with age. IV and SC NAD+ are used to restore cellular function; oral precursors (NR, NMN) are alternatives.
Standard dosing
Typical clinical use: 50-200 mg SC daily or 500-1000 mg IV weekly. Dosing varies by indication and provider protocol; this is reference-only and not a prescribing recommendation. NAD+ requires a prescription from a licensed clinician.
Regulatory status & pharmacy pathway
Not FDA-approved (compounded for SC/IV). FDA limits which peptides a pharmacy may compound; check this page’s dated FDA status notice before assuming a peptide is legally available. Ask which licensed pharmacy fills the prescription and check that pharmacy’s license with your state board of pharmacy.
U.S. telehealth providers prescribing NAD+
The most commonly cited U.S. telehealth providers for NAD+ are Defy Medical, Marek Health, Hone Health, Maximus, and PeterMD —, whose offerings for this peptide we have not verified (see the FDA status notice above). See the full provider directory for complete profiles.
Trade-offs to know
NAD+ carries the trade-offs common to all compounded peptide therapeutics: not FDA-approved, cash-pay only, no in-network insurance coverage, and pharmacy-quality variation between providers. Choose a prescriber that names its pharmacy, explains its follow-up schedule and states the regulatory status of what it prescribes.
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Editorial team
Researched by Dr. Parmis (Medical Researcher, Western University of Health Sciences); medically reviewed by Dr. Jonathan Snipes, MD and Kim Callender, NP (FNP-BC).