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Clinical Reference · Updated 2026-06-01

STEP Trial Results

STEP-1 through STEP-4 trials established semaglutide's weight-management efficacy. Pivotal STEP-1 (NEJM 2021, PMID 33567185): 14.9% mean weight loss at 2.4 mg / 68 weeks.

Clinical referencePubMed-linkedUpdated 2026-06-01
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Editorial team
Dr. Sam Saberian · Lead Medical Researcher
Medical review by Alen A. Schwartz, MD · Edited by Julliana Edwards · Last updated 2026-06-01

Overview

STEP-1 through STEP-4 trials established semaglutide's weight-management efficacy. Pivotal STEP-1 (NEJM 2021, PMID 33567185): 14.9% mean weight loss at 2.4 mg / 68 weeks.

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